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Coagulation Profile Test

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Coagulation disorder is a condition in which the body’s ability to clot the blood is impaired. This condition can cause prolonged or excessive bleeding, which may occur spontaneously or following an injury and dental procedures.

It can be caused by reduced levels or absence of blood clotting factors. It can also occur as a result of dysfunction or reduced levels of platelets (small disk-shaped bodies in the bloodstream that aid in the clotting process).

Major causes of coagulation disorders are:

  • Vitamin K deficiency
  • Liver disease (including cirrhosis, hepatitis, or acute fatty liver of pregnancy)
  • Disseminated intravascular coagulation
  • Overdevelopment of circulating anticoagulants (antibodies that decrease the activity of a specific clotting factor)
  • Deficiency of specific clotting factors (Hemophilia A, Hemophilia B)
  • Excessive bleeding during surgery
  • Bleeding into the joints
  • Bleeding into the brain
  • Gastrointestinal bleeding
  • Joint pain
  • Blood in urine or stool
  • Bruising easily and excessively
  • Nose bleed
    • von Willebrand disease(vWD)

It is a deficiency or defect of von Willebrand factor (vWF) which is an important carrier of clotting factor VIII and helps platelets adhere to the site of the blood vessel damage. The different types of von Willebrand disease include:

Type 1: where there is a partial deficiency of von Willebrand factor

Type 2: where there is a defect in von Willebrand factor

Type 3: where there is an almost complete deficiency of von Willebran factor

  • Hmophilia

It is a deficiency of one of the clotting factors involved in the coagulation cascade that eventually leads to the formation of a blood clot. Hemophilia A and B mainly affects males. There are three different types:

Hemophilia A: where there is a deficiency in factor VII

Hemophilia B: where there is a deficiency in factor IX

Hemophilia C: where there is a deficiency in factor XI


  • Thrombocytopenia purpura (TP)

It is due to a deficiency of circulating platelets, the cell particles that are essential for the formation of a platelet plug and contribute to blood clotting

Disorders of the coagulation can either be acquired after birth or they can be hereditary and passed down from the parents to the child.

Risk factors associated with developing a coagulation disorder include:

  • Parents with a hereditary coagulation disorder
  • Certain conditions, such as liver disease
  • Having a blood transfusion
  • Certain types of cancer
  • Blood infections
  • Pregnancy complications
    • Diagnosis

Diagnosis of coagulation disorders usually begins with a physical exam and a review of the patient's medical history and symptoms. A positive diagnosis of the condition is based on the patient's symptoms as well as the findings of a blood test. Other diagnostic tools may be used to better understand the patient's condition.

A blood test is the only way to positively diagnose a coagulation disorder. The blood sample will be examined under a microscope to determine the following information:

  • Complete blood count (CBC)
  • How long it takes the blood to clot (Partial thromboplastin time)
  • How long it takes the liquid (plasma) portion of the blood to clot (Prothrombin time)
  • Whether there are coagulation elements present (fibrinogen)
  • Other diagnostic tools may include magnetic resonance imaging (MRI) and computed tomography (CT) angiography, which can be used to observe the condition and the area affected by disorder.

    Preventive Measures

  • Iron supplementation
  • Blood transfusion
  • Other treatments (can be treated with topical products or nasal sprays)
  • Quit smoking
  • Maintain blood pressure
  • Follow healthy diet

Sexually Transmitted Diseases (STDs)

1. What is a coagulation disorder?+
ii.What can cause coagulation disorder?+
iii.What are the treatment options for people with coagulation disorder?+
iv. What are causes of coagulation disorder?+